We employ integrative structural biology to study the structure, mechanism, antagonism (and/or agonism) of proteins and protein complexes pivotal to immunity, inflammation, and cancer. Our research approach is fuelled by rigorous hypothesis-driven interrogation of the molecular targets under study and is closely nested in academic collaborations with leading research groups and the biotechnology/pharma sectors.
We currently focus on 3 main research topics:
- Pro-inflammatory signaling complexes and antagonist design.
- Extracellular assembly and activation principles of oncogenic receptor tyrosine kinases.
- In vivo protein crystals in immunity, inflammation, and cancer
- Cao L, et al. Design of protein binding proteins from target structure alone.
Nature, 605, 551-560, 2022.
- De Munck S., et al. Structure and mechanism of cytokine-mediated activation of ALK family receptors.
Nature, 600, 143-147, 2021.
- Persson E.K., Verstraete K., et al. Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364:6442, 2019.
- Verschueren K.H.G., et al. Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568:571-575, 2019.
- Liénart S., Merceron R., et al. Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells.
Science, 362, 952-956, 2018.