We employ an integrative structural biology approach in conjunction with molecular interaction studies and cellular interrogation of the systems under study to elucidate the structural and mechanistic principles underlying the assembly, activation and pathophysiology of macromolecular complexes pivotal to inflammation, immunity, and cancer. The cornerstone of our research philosophy lies in a rigorous hypothesis-driven interrogation of the protein complexes under study, and is closely nested in collaborations with leading academic research groups in Belgium and abroad as well as industrial partners.
We currently focus on 3 main research topics:
- Pro-inflammatory signaling complexes and antagonist design.
- Extracellular assembly and activation principles of oncogenic receptor tyrosine kinases.
- In vivo protein crystals in immunity, inflammation, and cancer
- Persson E.K., Verstraete K., et al. Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364:6442, 2019.
- Verschueren K.H.G., et al. Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568:571-575, 2019.
- Liénart S., Merceron R., et al. Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells.
Science 362, 952-956, 2018.
- Bloch Y., et al. Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1.
Immunity 48, 45–58, 2018.
- Verstraete K., et al. Structure and Antagonism of the Receptor Complex Mediated by Human TSLP in Allergy and Asthma.
Nature Communications, 8:14937, 2017.