PhD defences are open to the public, and take place in the J. Schell seminar room of the UGent-VIB research building, (unless otherwise specified).
Please check the IRC Calendar to know more about the upcoming PhD defences.
IRC Ph.D. theses since 2000
Pdf-versions of the theses are available on the IRC intranet only (login required
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- Murgaski Aleksandar (20-December-2022 ; D. Laoui & J. Van Ginderachter)

Understanding the effect and mechanisms of CD40 agonist therapy on tumour growth and dendritic cell vaccination strategies
- Xie Junhua (20-December-2022 ; R. Vandenbroucke, F. Haesebrouck & L. Van Hoecke)

Studying the impact of the gastrointestinal bacteria on the brain, focusing on the blood-cerebrospinal fluid barrier and Alzheimer's disease
- Moon Sangphil (20-December-2022 ; M. Radwanska & S. Magez)

Assessing impacts of experimental trypanosome infections on B cell memory
- Emmaneel Annelies (13-December-2022 ; Y. Saeys & S. Van Gassen)

Improving diagnosis of primary immunodeficiencies using computational cytometry
- Tulkens Dieter (9-December-2022 ; K. Vleminckx & P. Van Vlierberghe)

Uncovering novel cancer driver genes using CRISPR/Cas9 multiplexing in Xenopus tropicalis
- Heyndrickx Ines (25-November-2022 ; B. Lambrecht & H. Hammad)

The role of protein crystals in type 2 immunity
- Iliaki Stella (26-October-2022 ; R. Beyaert & I. Afonina)

Identification and functional characterization of CARD14 protein-protein interactions
- De Galan Cara (27-September-2022 ; D. Laukens & P. Hindryckx)

New insights in the use of vedolizumab in inflammatory bowel disease
- Vetters Jessica (2-September-2022 ; S. Janssens)

Novel pathways in NK cell biology
- Plehiers Nele (31-Augustus-2022 ; R. Vandenbroucke)

Hijacking receptor-mediated transcytosis at the blood-cerebrospinal fluid barrier as delivery route for drugs to the brain
- Cappe Benjamin (7-July-2022 ; P. Vandenabeele & F. Riquet)

Investigating the role of MLKL and EVs in cell-cell communication during necroptosis
- Pauwels Marie (28-June-2022 ; R. Vandenbroucke & L. Van Hoecke)

Exploration of blood-cerebrospinal fluid barrier targeted extracellular vesicles as brain delivery strategy
- Jonckheere Sven (24-June-2022 ; G. Berx & S. Goossens)

Therapeutic targeting of ZEB1-mediated EMT in metastatic colorectal cancer
- Remmerie Anneleen (13-June-2022 ; C. Scott & M. Guilliams)

Understanding Hepatic Macrophage Phenotypes and Functions in Metabolic-Associated Fatty Liver Disease
- Kim Seo Woo (18-May-2022 ; R. Beyaert, J. Staal & A. Goossens)

Unraveling the functional roles of endogenous phytohormones in mammals
- Holgado Muñoz Aurora (4-May-2022 ; R. Beyaert & I. Afonina)

Targeting and regulation of interleukin-33 signalling in lung inflammation
- Van Coillie Samya (10-Dec-2021 ; P. Vandenabeele & T. Vanden Berghe)

Therapeutic targeting of ferroptosis in experimental models of acute organ injury
- Delanghe Tom (10-Dec-2021 ; M.J. Bertrand & Y. Dondelinger)

Unraveling the role of RIPK1 phosphorylation in TNF-mediated cell death and inflammation
- Vanderhaeghen Tineke (6-Dec-2021 ; C. Libert & R. Beyaert)

The Effect of Hypoxia and Hypoxia Inducible Factors on the Glucocorticoid Receptor Function and their Role during Sepsis
- Srinivasan Sahana (3-Dec-2021 ; G. van Loo & M. Lamkanfi)

Characterizing the role of microglial inflammation in neurodegeneration
- Oltean Teodora (30-Nov-2021 ; P. Vandenabeele, J. Maelfait & S. Adjemian Catani)

Unraveling cell death modalities during influenza infection, vaccination, and cancer therapy
- Van Hove Lisette (19-Oct-2021 ; E. Hoste & G. van Loo)

Unravelling molecular mechanisms mediating skin inflammation and tumour formation
- Fernandes Côrte-Real Beatriz (30-Sep-2021 ; M. Kleinewietfeld)

The impact of high salt on Foxp3+ regulatory T cell metabolism and function
- Wiernicki Bartosz (27-Sep-2021 ; P. Vandenabeele, T. Vanden Berghe & K. Ravichandran)

The role of lipid peroxidation in cell death and adaptive immune system regulation
- Vrancken Kurt (21-Sep-2021 ; P. Brouckaert & A. Blood)

Plasma nitric oxide handling and its metabolism to endocrine S-nitrosothiol and nitrite: Role of ceruloplasmin and a novel function for postprandial triglyceride rich lipoproteins
- De Schutter Elke (8-Sep-2021 ; G. Van Camp, P. Vandenabeele & F. Riquet)

Elucidation of the role of GSDME during apoptosis-driven secondary necrosis
- Percier-Lehebel Pauline (24-Aug-2021 ; W. Declercq, J. Grooten & O. Denis)

Alternaria alternata and Aspergillus fumigatus mold species counteract experimental mycobacterial and allergic lung diseases through divergent innate immune mechanisms
- De Munck Steven (12-Jul-2021 ; S. Savvides)

Structure and mechanism of cytokine mediated activation of ALK family receptor tyrosine kinases
- De Vos Tatjana (8-Jul-2021 ; S. Savvides)

Structural basis for the activation and antagonism of the IL-9 signaling complex
- Loret Nele (08-Jun-2021 ; G. Berx, B. Lambrecht & P. Tummers)

Cellular plasticity and heterogeneity in ovarian cancer progression and therapy resistance
- T'Jonck Wouter (28-Apr-2021 ; C. Scott)

Notch-induced LXRα expression is essential for the maintenance of Kupffer cell identity
- Renson Thomas (15-Apr-2021 ; D. Elewaut, F. Van den Bosch & J. Dehoorne)

Identifying pitfalls and opportunities of magnetic resonance imaging in spondyloarthritis
- Cloots Eva (12-Apr-2021 ; S. Janssens & S. Eyckerman)

The ins and outs of IRE1B signaling: the role of IRE1B in mucosal homeostasis
- Vandewalle Jolien (24-Mar-2021 ; C. Libert & K. De Bosscher)

The role of glucocorticoid resistance and TNFR1 signaling in sepsis
- Bosteels Cédric (26-Feb-2021 ; B. Lambrecht & H. Hammad)

The role of DC subsets in respiratory viral infections and vaccination: a case of mistaken identity
- Vandendriessche Charysse (17-Dec-2020 ; R. Vandenbroucke & C. Van Cauwenberghe )

Exploring the role of extracellular vesicles in Alzheimer’s and Parkinson’s disease
- Todorov Helena (16-Dec-2020 ; Y. Saeys & J. Marvel )

Structure learning to unravel mechanisms of the immune system
- Dimitrakopoulou Dionysia (16-Oct-2020 ; K. Vleminckx & A. Willaert)

CRISPR/Cas9 mediated modeling of TP53 and PTEN related malignancies in Xenopus tropicalis
- Gorlé Nina (19-Jun-2020 ; R. Vandenbroucke & F. Haesebrouck)

Study of the importance of the choroid plexus in peripheral and brain inflammation
- Gilis Elisabeth (29-May-2020 ; D. Elewaut & S. Lambrecht)

The role of MALT1 in rheumatic diseases
- Zuallaert Jasper (27-May-2020 ; W. De Neve, N. Callewaert & Y. Saeys)

Automated learning of biologically relevant features from primary sequence using convolutional neural networks
- Priem Dario (22-Apr-2020 ; M. Bertrand)

The ubiquitin-dependent regulation of the inflammatory response by A20 and MAGED1
- Van Wyngene Lise (19-Mar-2020 ; C. Libert & G. van Loo)

The role of hepatic PPARa in sepsis and ZBTB32 in metabolic homeostasis
- Van Looveren Kelly (13-Mar-2020 ; C. Libert & K. De Bosscher)

The glucocorticoid receptor in acute inflammation: new molecular insights and development of a new GR dimerization mutant
- Martens Arne (11-Feb-2020 ; G. van Loo)

Mechanistic insights into the regulation of inflammatory pathology by A20
- Cannoodt Robrecht (16-Dec-2019 ; Y. Saeys & K. De Preter)

Modelling single-cell dynamics with trajectories and gene regulatory networks
- Debeuf Nincy (13-Dec-2019 ; B. Lambrecht & S. Janssens)

ORMDL3 in the regulation of sphingolipid synthesis and in the pathogenesis of allergic asthma
- Detry Sammy (9-Dec-2019 ; S. Savvides & Y. Bloch)

Unraveling and targeting of molecular signaling mechanisms of IL-12 family, IL-18 and IL-33 cytokines using integrative structural biology
- Saelens Wouter (24-Oct-2019 ; Y. Saeys & B. Lambrecht)

Developing and benchmarking methods for analysing transcriptomics data
- Brkic Marjana (27-Sep-2019 ; R. Vandenbroucke, S. Kanazir & C. Libert)

Studies on structural and functional changes of mouse choroid plexus in the initiation of neuroinflammation
- Dubois Hanne (17-Sep-2019 ; A. Wullaert & M. Lamkanfi)

Characterisation of innate immune responses associated with gastrointestinal norovirus infection
- Vanderkerken Matthias (16-Sep-2019 ; B. Lambrecht & T. Kerre)

Molecular interactions controlling immune homeostasis in the marginal zone
- Bauwens Eva (3-Sep-2019 ; R. Vandenbroucke, F. Haesebrouck, A. Smet)

Impact of gastric Helicobacter infections on the stomach-brain axis
- Martens Sofie (4-Jul-2019 ; P. Vandenabeele, V. Goossens, N. Takahashi)

Necroptotic proteins in diseases: targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development
- Sabaghian Ehsan (1-Jul-2019 ; Y. van de Peer & Y. Saeys)

Unravelling gene functions in Arabidopsis thaliana by means of network biology and machine learning
- Van Nuffel Elien (27-Jun-2019 ; R. Beyaert & I. Afonina)

CARD14/MALT1 signaling in skin homeostasis and disease
- Naert Thomas (21-Jun-2019 ; K. Vleminckx)

CRISPR/Cas9-mediated cancer modeling and identification of cancer cell vulnerabilities in Xenopus tropicalis
- Bolli Evangelia (19-Jun-2019 ; J. Van Ginderachter)

Nanobody-mediated targeting of tumor-associated macrophages for cancer therapy
- Cambré Isabelle (4-Jun-2019 ; D. Elewaut & S. Lambrecht)

Mechanical strain and its implications for mouse and human rheumatic diseases
- De Smedt Eva (23-May-2019 ; G. Berx)

ZEB1 as 'jack-of-all-trades' in breast cancer progression
- Roels Joris (3-May-2019 ; Y. Saeys & W. Philips)

Automated Segmentation of 3D Electron Microscopy Images
- Voet Sofie (15-Mar-2019 ; G. van Loo)

Study of inflammatory signaling and microglia activation in central nervous system pathology
- Lork Marie Therese (8-Mar-2019 ; R. Beyaert, J. Staal)

Molecular regulation of T cell receptor signaling
- Vandersarren Lana (27-Feb-2019 ; S. Janssens, B. Lambrecht)

ER stress and T cell biology: IRE1 signaling and TAOK3 function
- Haspeslagh Eline (14-Feb-2019 ; H. Hammad, B. Lambrecht)

Pulmonary immunomodulation of house dust mite-induced allergic asthma
- Pannecoucke Erwin (14-Feb-2019 ; S. Savvides)

An integrative approach towards unraveling the activation of oncogenic FLT3
- Pauwels Anne-Marie (7-Jan-2019 ; R. Beyaert, Hoffmann E.)

Impact of TLR4 engagement on the phagosomal proteome in dendritic cells and consequences for antigen degradation and presentation
- Mamantopoulos Michail (19-Dec-2018 ; A. Wullaert, M. Lamkanfi)

Inflammasomes in intestinal host-microbe interactions
- Timmermans Steven (11-Dec-2018 ; C. Libert, Y. Saeys)

Identifying and classifying protein coding gene polymorphisms between laboratory mouse strains and investigating glucocorticoid actions in sepsis models
- Souffriau Jolien (7-Dec-2018 ; C. Libert)

Targeting TNF-induced acute inflammation by making use of SEDIGRAM or zinc
- Fulara Aleksandra (7-Dec-2018 ; S. Savvides)

Study of the GspLM complex, an inner membrane component of the type II secretion system from Pseudomonas aeruginosa
- Vluymans Sarah (29-June-2018 ; Y. Saeys, C. Cornelis)

Dealing with Imbalanced and Weakly Labelled Data in Machine Learning using Fuzzy and Rough Set Methods
- Godar Marie (29-June-2018 ; B. Lambrecht, C. Blanchetot)

Development of Novel Multifunctional Antibodies to Treat Asthma
- Saavedra Pedro H. V. (26-June-2018 ; A. Wullaert, M. Lamkanfi)

Mechanism and functions of the cytosolic receptor Pyrin
- Moraes de Vasconcelos Nathalia (26-June-2018 ; A. Wullaert, M. Lamkanfi)

Cell death signaling at the crossroads of inflammasome activation
- Slowicka Karolina (21-June-2018 ; G. van Loo, L. Vereecke)

Study of intestinal homeostasis and pathology through mouse gene targeting
- Soen Bieke (30-May-2018 ; G. Berx)

Zeb1 and Zeb2: master regulators of mononuclear phagocyte development and homeostasis
- De Keuckelaere Evi (22-May-2018 ; F. Van Roy, G. Berx)

The role of Nanos3 in tumor progression
- Kip Elodie (9-May-2018 ; R. Beyaert, S. De Gucht)

Impact of the paracaspase MALT1 on rabies virus-induced neuroinflammation and disease
- Sundararaman Srividhya (26-Apr-2018 ; F. Van Roy, K. Vleminckx)

Cadherin repertoires in lower metazoans - Trichoplax adhaerens and Nematostella vectensis
- Bloch Yehudi (16-Apr-2018 ; S. Savvides, K. Verstraete)

Structure, mechanism, and antagonism of the pro-inflammatory receptor complex mediated by interleukin-23
- Carron Philippe (30-Mar-2018 ; D. Elewaut, F. Van den Bosch)

New Imaging modalities and treatment strategies in Spondyloarthritis
- Delvaeye Tinneke (9-Mar-2018 ; P. Vandenabeele, D. Krysko, L. Leybaert)

The pathological role of Cx43 and MLKL in TNF-induced Systemic Inflammatory Response Syndrome
- Noelanders Rivka (1-Mar-2018 ; K. Vleminckx)

Wnt/beta-catenin signaling in the Xenopus hindbrain: development and cancer
- Tanghe Giel (23-Feb-2018 ; W. Declercq)

Mechanistic insights into the regulation of RIPK4 and its function in skin homeostasis and pathology
- Berings Margot (21-Feb-2018 ; M. Dullaers, P. Gevaert, B. Lambrecht)

House dust mite allergic rhinitis: A novel take on diagnosis and treatment
- Varkas Gaëlle (20-Feb-2018 ; D. Elewaut, F. Van den Bosch)

Axial spondyloarthritis: New insights in diagnosis and patient stratification
- D'hondt Sanne (15-Dec-2017 ; F. Malfait, S. Janssens & M. Bertrand)

Type III collagen, a major fibrillar collagen with major issues
- Dendoncker Karen (13-Oct-2017 ; C. Libert)

Elucidating the mechanism behind TNF-induced glucocorticoid resistance and strategies to overcome this resistance
- Steeland Sophie (5-Oct-2017 ; C. Libert & R. Vandenbroucke)

Therapeutic targeting of inflammatory mediators in sepsis and neurodegenerative diseases
- Favreau Mérédis (4-Oct-2017 ; D. Elewaut, K. Venken, E. Menu & K. Vanderkerken)

Immune therapy in multiple myeloma: Can iNKT cells be targeted?
- Abels Chloé (26-Sep-2017 ; J. Van Ginderachter, P. De Baetselier & A. Beschin)

Unravelling the role of liver associated myeloid cells in sterile inflammation and infection
- De Wilde Katelijne (20-Sep-2017 ; D. Elewaut & S. Lambrecht)

Novel myeloid regulators of rheumatic diseases
- Bogaert Delfien (4-Sep-2017 ; M. Dullaers, F. Haerynck & E. De Baere)

Molecular diagnosis of Common Variable Immunodeficiency and related antibody disorders: an integrated immunological and genetic approach
- Van der Borght Katrien (7-Jul-2017 ; B. Lambrecht)

Cardiac dendritic cells activate autoreactive T cells in the healthy and diseased heart
- Deckers Julie (5-Jul-2017 ; H. Hammad & K. De Bosscher)

The skin as a central player in house dust mite allergy
- Aaes Tania Love (5-Jul-2017 ; P. Vandenabeele & D. Krysko)

The impact of cell death modalities on the immunogenicity of cancer cells
- Vandamme Niels (26-Jun-2017 ; G. Berx)

ZEB1 and ZEB2 dictate melanocyte homeostasis and melanoma phenotype switching
- Ruyssinck Joerie (19-Jun-2017 ; Y. Saeys & T. Dhaene)

Machine Learning for Biological Network Inference
- Krols Michiel (13-Jun-2017 ; S. Janssens & V. Timmerman)

Mutations in Atlastin-3: implications for ER membrane fusion and crosstalk with mitochondria
- Le Cann Fabienne (2-Jun-2017 ; P. Vandenabeele)

Characterization of new necroptosis innhibitors targeting RIPK1
- Udhayakumar Vimal Kumar (24-May-2017 ; J. Grooten & S. De Koker)

Development and validation of synthetic-virus like vaccines
- Van Gassen Sofie (23-May-2017 ; Y. Saeys & T. Dhaene)

Development of Machine learning techniques for flow cytometry data
- Govindarajan Srinath (16-May-2017 ; D. Elewaut & M. Drennan)

Mechanistic insights into the regulation of iNKT development and cytokine production
- Schuijs Martijn (14-Apr-2017 ; H. Hammad and B. Lambrecht)

The Pathogenesis of House Dust Mite-driven Asthma: From Barn to Bedside
- Ladik Maria (4-Apr-2017 ; P. Vandenabeele)

Development of biosensing systems to monitor necroptosis
- Van Nieuwenhuysen Tom (31-Mar-2017 ; K. Vleminckx)

Modeling human disease in Xenopus tropicalis using programmable nucleases
- Urwyler-Rösselet Corinne (17-Mar-2017 ; W. Declercq & P. Vandenabeele)

Study of the functions of RIPK4 in epidermal development and signal transduction
- Balusu Sriram (15-Mar-2017 ; R. Vandenbroucke & C. Libert & K. Gevaert)

Novel insights into the choroid plexus response to systemic inflammation and Alzheimer's disease
- Vermeulen Ilke (3-Mar-2017 ; J. Grooten)

Tuberculosis: how different synthetic analogues of pathogen associated mycolates affect lipid homeostasis of murine host macrophages
- Catrysse Leen (24-Feb-2017 ; G. van Loo & R. Beyaert)

Diabetes and inflammation, how A20 regulates tissue homeostasis in metabolic tissues
- Sichien Dorine (24-Feb-2017 ; B. Lambrecht & M. Guilliams)

Differential requirement for IRF8 in the development and function of monocytes and dendritic cells
- Tavernier Simon (31-Jan-2017 ; B. Lambrecht & S. Janssens)

Dendritic cells under stress: on the role of the unfolded protein response and hypoxia signalling
- Cypers Heleen (23-Jan-2017 ; D. Elewaut)

The role of intestinal inflammation in initiation, monitoring and outcome of spondyloarthritis
- De Beuckelaer Ans (23-Dec-2016 ;J. Grooten)

mRNA-based vaccines to elicit CD8 T cell immunity
- Borghi Alice (22-Dec-2016 ;R. Beyaert)

New insight into the ubiquitin-mediated regulation of TNFR2 signaling
- Hassannia Behrouz (22-Dec-2016 ;P. Vandenabeele)

Ferroptosis: triggers, inhibitors and therapeutic potential in neuroblastoma
- Van Putte Wouter (19-Dec-2016 ;S. Savvides)

The type II secretion system and membrane vesiculation: bacterial secretion systems as a target for anti-virulence drug development
- Meloni Laura (8-Dec-2016 ;R. Beyaert)

Molecular mechanisms of mechanotransdcution and osteoclastogenesis in arthritis
- Gül Ismail Sahin (6-Dec-2016 ;F. Van Roy)

Molecular evolution of the armadillo repeat superfamily and characterization of representative members in key model organisms
- Demeestere Delphine (2-Dec-2016 ;C. Libert & R. Vandenbroucke)

A study of inflammatory mechanisms involved in systemic inflammation and brain trauma
- Ballegeer Marlies (2-Dec-2016 ;C. Libert & R. Vandenbroucke)

Study of the role and regulation of Glucocorticoid induced leucine zipper (GILZ) and GR dimers in acute inflammation
- Neyt Katrijn (21-Oct-2016 ;B. Lambrecht & M. Guilliams)

Pulmonary immune responses against influenza A virus infection
- Jimenez Fernandez Daniel (22-Sep-2016 ;L. Lamkanfi & K. Gevaert)

Functional characterization of inflammatory caspases
- Billi Eleonora (22-Sep-2016 ; F. Van Roy & J. Tavernier)

Identification and functional analysis of molecular interaction partners of δ-protocadherin family members with putative roles in cancer
- Sips Magdalena (31-Aug-2016 ; P. Brouckaert)

Harnessing innate immunity to prevent and control HIV infection
- Demeyer Annelies (28-Jun-2016 ; R. Beyaert)

Functional characterization of the paracaspase MALT1 in T cells
- Grootjans Sasker (15-Apr-2016 ; P. Vandenabeele)

Identification of potential RIPK1 substrates during Necroptosis
- Aguileta Miguel (15-Apr-2016 ; M. Bertrand & P. Vandenabeele)

Characterization of new proteins involved in apoptosis regulation
- Juchtmans Nele (22-Mar-2016 ; D. Elewaut)

The role of stress related proteins in osteoarthritis
- Félix Jan (7-Jan-2016 ; S. Savvides)

Structural Principles of binding duality in cognate and viral cytokine receptors
- Petta Ioanna (4-Dec-2015 ; C. Libert & J. Tavernier)

Identification of striatin-3 and ZBTB32 as two novel modulators of glucocorticoid receptor activity
- Sipieter François (3-Dec-2015 ; F. Riquet, P. Vandenabeele, K. Cailliau-Maggio & L. Héliot)

Development and validation of kinase activity reporters for the dynamical study of cell response modalities by microscopy ~ Role of the kinase MAPK/ERK in necroptosis.
- Deng Lei (3-Dec-2015 ; X. Saelens)

Targeted prokaryotic delivery of a conserved influenza A virus epitope for oral vaccination
- Santens Francis (25-Sep-2015 ; N. Callewaert)

Engineering of protein production systems to drastically reduce glycan heterogeneity of biopharmaceuticals
- Claes Katrien (11-Sep-2015 ; N. Callewaert)

Development of modular engineering tools for membrane protein expression in yeast
- Dondelinger Yves (3-Jul-2015 ; P. Vandenabeele & M. Bertrand)

Unraveling the molecular mechanisms of RIPK1-mediated cell death
- Vandewalle Kristof (19-Jun-2015 ; N. Callewaert)

Building genome-wide mutant resources in slow-growing mycobacteria
- De Visscher Charlotte (20-Feb-2015 ; N. Callewaert)

Engineering of the production of mannose-6-phosphate-modified lysosomal enzymes by the yeast Pichia pastoris
- Elton Lynn (19-Dec-2014 ; R. Beyaert)

Identification and functional characterization of novel MALT1 substrates
- Smet Muriel (18-Dec-2014 ; J. Grooten)

Cholesterol-sensing liver X receptors and mycolic acid bio-lipids at the crossroads of lipid metabolism and inflammation
- Mueller Christina (16-Dec-2014 ; R. Beyaert)

Molecular and functional characterization of interleukin-33 signaling
- Volckaert Thomas (8-Dec-2014 ; R. Beyaert)

Epithelial-mesenchymal crosstalk during lung development and regeneration
- Grine Lynda(25-Nov-2014 ; C. Libert)

Study of the role of type I Interferons in TNF-mediated inflammation.
- Tyberghein Koen (30-Sep-2014 ; F. Van Roy)

Alpha-catenins: protein replacement as a strategy against cancer invasion and metastasis?
- Ydens Elke (24-Apr-2014 ; S. Janssens & V. Timmerman)

Activation of the innate immune response during peripheral nerve degeneration: from pattern recognition receptors to immune effector cells
- Broos Stefan (24-Jan-2014 ; F. Van Roy & P. De Bleser)

Developing algorithms for the in silico identification of transcription factor binding sites
- Vandendriessche Benjamin (13-dec-2013 ; P. Brouckaert & A. Cauwels)

Complex dynamics in systemic inflammation: quantification of coupling and targeting of the nitric oxide-soluble guanylate cyclase axis
- Pollard Charlotte (6-dec-2013 ; J. Grooten & S. De Koker)

Evaluation of CD8+ T cell responses upon mRNA vaccination and the implication of type I IFN signaling
- Puimège Leen (29-nov-2013 ; C. Libert)

A molecular genetic analysis of TNFR1 regulation in SPRET/EI and generation of new TNFR1 inhibitory tools
- Vandevyver Sofie (22-nov-2013 ; C. Libert)

Study of the molecular mechanisms of glucocorticoid receptor function and resistance in TNF-induced toxicity
- Plantinga Maud (16-Oct-2013 ; Bart Lambrecht)
The role of dendritic cell subsets in allergic sensitization
- Ayiseh Rene B. (19-Sep-2013 ; P. Vandenabeele)

Role of cell death and caspases in intestinal inflammation
- Kaczmarek Agnieszka (4-Jul-2013 ; P. Vandenabeele)

Sensing of apoptotic and necroptotic cell death by the innate immune system
- Willart Monique (27-Jun-2013 ; B. Lambrecht)

Immune activation at the lung epithelial barrier
- McGuire Conor (31-May-2013 ; G. van Loo & R. Beyaert)

The study of signaling pathways controlling central nervous system inflammation and pathology
- De Baets Sarah (10-Apr-2013 ; X. Saelens)

Novel vaccination strategies against human repiratory syncytial virus
- Pringels Sarah (17-Apr-2013 ; J. Grooten)

Screening of the Vascular Endothelial Growth Factor family in human colon cancer
- Cardoso Francisco Miguel Lopez (28-Feb-2013 ; X. Saelens)

Antiviral activity of camelid single domain antibodies targeting the neuraminidase of H5N1 Influenza virus
- De Groote Philippe (21-dec-2012 ; W. Declercq)

Study of RIPK4 function in skin homeostatsis and disease
- Devos Michael (21-dec-2012 ; W. Declercq)

Study on the role of delatNp63alpha and caspase-14 in skin homeostasis and pathology
- Kahr Irene (20-dec-2012 ; F. Van Roy)

Functional analysis of the candidate tumor suppressor protein protocadherin-10
- Verhelst Judith (19-dec-2012 ; X. Saelens)

Unraveling the antiviral mechanism of mouse Mx1 directed against influenza A
- Janssens Sylvie (19-Oct-2012 ; K. Vleminckx)

Identification of novel target genes of the Wnt/β-catenin pathway during Xenopus development and analysis of their epigenetic regulation
- Haenebalcke Lieven (5-Oct-2012 ; J. Haigh)

Generation and use of novel ROSA26-based ESC/iPSC technologies to study cellular reprogramming and gene function during lineage-directed differentiation
- Naessens Thomas (6-Jul-2012 ; J. Grooten)

Functional dynamics of resident alveolar macrophages in a mouse model of allergic asthma
- Vander Beken Seppe (6-Jul-2012 ; J. Grooten)

Mycobacterium tuberculosis bio-lipid mycolic acid and mammalian cholesterol-sensor liver X-receptor in airway immunity
- Farhang Ghahremani Morvarid (5-Jul-2012 ; J. Haigh)

Molecular and genetic interplay between p53 and VEGF in tumour angiogenesis
- Meuris Leander (2-Jul-2012 ; N. Callewaert)

GlycoDelete: a new glycoengineering concept for protein production in mammalian cells
- Nittner David (8-Jun-2012 ; J.C. Marine)

Role of the microRNA pathway in retinoblastoma
- Guerfal Mouna (8-May-2012 ; N. Callewaert)

Yeast secretory system engineering for enhanced membrane protein expression
- Roose Kenny (26-Jan-2012 ; X. Saelens)

Design and validation of novel broad influenza B vaccine
- Andries Vanessa (26-Jan-2012 ; F. Van Roy)

Functional analysis of the NBPF1 gene in cancer
- Bekaert Tine (20-Jan-2012 ; R. Beyaert)

Functional characterization of the paracaspase MALT1
- Gembarska Agnieszka (19-Jan-2012 ; J.C. Marine)
MDMX is a key therapeutic target in skin melanoma
- Schotsaert Michael (16-Dec-2011 ; X. Saelens)

Modulation of humoral and cellular immunity to influenza by vaccination
- Zwolinska Aleksandra (15-Dec-2011 ; J.C. Marine)

Study of three putative nuclear modulators of the p53 pathway
- Fransen Mathias (9-Dec-2011 ; K. Vleminckx)

Exploring the role of caspases and RIPK4 during Xenopus development
- Van Hauwermeiren Filip (25-Nov-2011 ; C. Libert)

New strategies to prevent TNF-induced toxicity in TNF/IFNgamma-based anti-tumor models
- Gheldof Alexander (21-Oct-2011 ; G. Berx)

Functional analysis of the EMT inducing transcription factor ZEB1 during malignant carcinoma progression
- Duprez Linde (14-Oct-2011 ; P. Vandenabeele)

Role of RIP1 in TNF-induced cell death in vitro and in vivo
- Tatari Marianthi (26-Sep-2011 ; G. Berx)

In vivo analysis of the role of ZEB2 in epithelial homeostasis and tumor progression
- Pinheiro Iris (8-Jul-2011; C. Libert)

Molecular cloning of the X-chromosome located LPS-resistance gene of SPRET/Ei mice
- Maelfait Jonathan (8-Jul-2011; R. Beyaert)

Signaling in antiviral immunity and its regulation by the ubiquitin-editing protein A20
- Lambertz Irina (6-Jul-2011; J.C. Marine)

MicroRNA control of cancer development
- Vanlangenakker Nele (1-Jul-2011; P. Vandenabeele)

Unraveling TNF-induced necrotic signaling pathways using RNA interference and live-cell imaging
- Quimbaya Mauricio (23-Jun-2011; L. De Veylder & G. Berx)

Identification of novel conserved cell cycle genes through data integration and comparative genomics between plants and humans
- Verhelst Kelly (17-Jun-2011; R. Beyaert)

Molecular analysis of the ubiquitin-editing protein A20
- Vereecke Lars (27-May-2011; R. Beyaert)

Controlling inflammation and cell death at the intestinal epithelial interface and beyond: Lessons from conditional 120 knockout mice
- De Pourcq Karen (27-May-2011; N. Callewaert)

Glycosylation engineering in the yeast Yarrowia lipolytica: creating an expression system to produce complete homogeneous glycoproteins
- Wirawan Ellen (8-Apr-2011; P. Vandenabeele)

Molecular interplay between autophagy and apoptosis through caspase-mediated cleavage of Beclin-1
- Kersse Kristof (8-Apr-2011; P. Vandenabeele)

Inflammasome modulation and NF-kB activation by caspase-1-related CARD domains
- Dejonckheere Eline (1-Apr-2011; C. Libert)

The role of matrix metalloproteinase 8 in TLR4-mediated acute systemic inflammation
- Pieters Tim (25-Feb-2011; F. Van Roy)

Functional analysis of mice harboring a knock-out or knock-in of the alternatively spliced exon C of p120ctn
- Hooghe Bart (25-Feb-2011; F. Van Roy)

In silico approaches to studying transcriptional gene regulation: prediction of transcription factor binding sites and applications thereof
- De Clercq Sarah (5-Jul-2010; J.-C. Marine)

Study of the physiological and oncogenic properties of Mdm2 and Mdm4
- Van Bogaert Tom (1-Jul-2010; C. Libert)

Study of the molecular mechanism of glucucorticoid resistance in tumor necrosis factor-induced systemic inflammation
- Galle Marlies (1-Jul-2010; R. Beyaert)

Modulation of macrophage immune responses by the Pseudomonas aeruginosa type three secretion system
- Hoste Esther (24-Jun-2010; W. Declercq & P. Vandenabeele)

Study of the role of caspase-14 in epidermal cornification
- Lefever Tine (3-Jun-2010; F. Van Roy)

Analysis of N-WASP function in keratinocytes in vivo
- Vanderschaeghe Dieter (1-Jun-2010; J. De Langhe & N. Callewaert)

GlycoHepatoTest: validation and analytical technology development for implementation on microfluidics analyzer
- Dejager Lien (30-Apr-2010; C. Libert)

Molecular and genetic analysis of the resistance of the mouse strain SPRET/Ei to endotoxemia and Gram-negative sepsis
- Houthuys Erica (2-Apr-2010; P. Brouckaert)

Transcriptome analysis of monocytes and macrophages in mycobacterial infection and chronic kidney disease
- Thoonen Robrecht (26-Feb-2010; P. Brouckaert)

Generation and characterization of apo-soluble Guanylate Cyclase mice
- Vanhooren Valerie (27-Nov-2009; C. Libert)

Glycomics of mammalian aging
- Crabbe Ellen (20-Nov-2009; K. Vleminckx)

Identification and functional characterization of novel N-cadherin interacting proteins
- Willemarck Nicolas (20-Nov-2009; K. Vleminckx)

Het Xenopus embryo als experimenteel platform voor de exploratie van nieuwe functies voor caspasen en tumorgeassocieerde de novo lipogenese
- Schoonooghe Steve (19-Oct-2009; J. Grooten)

Multivalent and cross-reactive bispecific bibodies and tribodies for enhanced MUC1 tumour targeting
- Vanlaere Ineke (24-Sep-2009; C. Libert)

Role of MMP-7 and IL-17A in acute systemic inflammation
- Demon Dieter (22-Jun-2009; P. Vandenabeele)

Caspase-7: protease specificity activation and construction of a conditional knockout
- Tran Hong Thi (19-Jun-2009; K. Vleminckx)

Development and use of novel transgenic lines to study Wnt signaling in the Xenopus embryo
- Huang Lieven (7-Jan-2009; R. Beyaert/P. De Baetselier)

Characterization of EGF receptor targeting Nanobodies and ABIN for the treatment of EGF receptor-dependent tumours
- De Koker Stefaan (28-Oct-2008; N. Mertens/J. Grooten)

Polyelectrolyte microcapsules for antibody delivery
- Huyghe Leander (10-Oct-2008; P. Brouckaert)

Study of molecular and immunological factors that determine the sensitivity to the antitumor effect of Tumor Necrosis factor
- Bogaert Pieter (27-Mar-2008; J. Grooten)

Transcriptome profiling of macrophage activation and inflammatory mediator expression in experimental mouse models of allergic pulmonary
inflammation
- Jacobs Pieter (29-Feb-2008; N. Callewaert)

Glycosylation and cell surface engineering in Pichia pastoris
- Vandewalle Cindy (28-Feb-2008; G.Berx & F. Van Roy)

The role and mechanisms of SIP1 in the dedifferentiation of epithelial
cancers
- Beekman Chantal - (21-Jan-2008; J.-C. Marine & F. Van
Roy)

A study of three putative players in the p53 pathway: Nucleostemin,
Ptprv and TCTP
- Verschuere Veerle - (20-Dec-2007; K. Vleminckx)

Analysis of the role of the p120 catenin subfamily in cell adhesion and
cell migration during the early development of Xenopus laevis
- Loos Michaela - (7-Dec-2007; E. Remaut)

Modulation of dendritic cell function through delivery of effector proteins by genetically modified Lactococcus lactis
- Coornaert Beatrice - (30-Nov-2007; R. Beyaert)

MALT1 paracaspase-mediated regulation of the NF-kappaB inhibitory protein A20 in antigen receptor signaling
- Van Huynegem Karolien - (23-Nov-2007; E. Remaut)

Genetically modified Lactococcus lactis as a tool in the prevention and healing of chemotherapy-induced intestinal mucositis
- Ovaere Petra - (5-Oct-2007; P. Vandenabeele)

Identification of a Caspase-14 activating protease in murine skin
extracts
- Verstrepen Lynn - (5-Oct-2007; R. Beyaert)

Functional characterization of ABIN-3 and TAX1BP1 as negative regulators of NF-kappaB signaling
- Vande Walle Lieselotte - (28-Sep-2007; P. Vandenabeele)

Role of the mitohondrial serine protease HtrA2/Omi in apoptosis
- Sips Patrick (6-Jul-2007; P. Brouckaert)

Functional analysis of soluble guanylate cyclase isoforms using mouse transgenics: cardiovascular effects of targeted mutagenesis of the alpha 1 subunit
- Vercammen Elisabeth (22-Jun-2007; R. Beyaert)

The secret life of Interleukin-1beta: molecular mechanisms involved in its production and biological activities
- Goethals An (11-May-2007; P. Brouckaert)

Studie in muismodellen van de mechanismen verantwoordelijk voor het antitumoraal effect van Tumor Necrosis Factor
- Van Lint Philippe (20-apr-07, 16h30; C. Libert)

The role of matrix metalloproteinases in specific inflammatory disorders
- Van Roy Maarten (20-apr-07, 14h00; C. Libert)

New strategies to improve the safety and efficacy of a TNF/IFNgamma-based antitumor therapy
- Schepens Bert (6-Oct-2006; R. Beyaert)

The great escape: how Internal Ribosome Entry Sites can initiate translation of crucial mRNAs during hypoxia and mitosis
- De Smet Kris (29-Sep-2006; R. Contreras)

Studie van het celdoodproces in Candida albicans
- Schauvliege Reinout (29-Sep-2006; R. Beyaert)

Molecular mechanisms of LPS-induced pro-inflammatory signalling
- Delvaye Mieke (28-Sep-2006; F. Van Roy & K.
Vleminckx)

Analysis of the morphogenetic role of known and novel cadherin-interacting proteins in Xenopus laevis
- Festjens Nele (7-Jul-2006; P. Vandenabeele & X.
Saelens)

Characterization of molecular mechanisms associated with and involved in necrotic cell death
- Krysko Dmitri (5-Jul-2006; K. D'Herde & P.
Vandenabeele)

Cell death: Initiation, propagation and clearance
- Laukens Debby (29-Jun-2006; E. Remaut & P.
Rottiers)

Transcriptome profiling and genetic analysis to identify and characterize susceptibility genes for Crohn's disease
- Wullaert Andy (5-May-2006; R. Beyaert)

Effect of ABINs on intracellular signaling pathways involved in TNF-mediated liver injury
- Mahieu Tina (31-Mrch-2006; C. Libert)

A molecular analysis of the LPS resistance of the mouse species /Mus spretus
- Bultinck Jennyfer (16-Mrch-06; P. Brouckaert)

(Sub)cellular expression patterns and pathophysiological significance of INOS in inflammatory shock
- Goossens Steven (24-Feb-06; F. Van Roy)

Functional analysis of mouse alpha T-catenin
- Heirman Ingeborg (1-Feb-06; J. Grooten)

The tumor cell oxidative status and its interaction with eicosanoid synthesis in the control of tumor growth and malignant progression
- Vandepoele Karl (22-Dec-2005; F. Van Roy)

Genomic characterization and functional analysis of the novel NBPF gene family
- Termont Sofie (16-Dec-2005; E. Remaut & P.
Rottiers)

Optimization of Lactococcus lactis mediated mucosal delivery of
cytokines
- Ryckaert Stefan (9-Dec-2005; R. Contreras)

Ontwikkeling van nieuwe toepassingen voor gist oppervlakte-expressie
- Soubry Adelheid (6-Dec-2005; F. Van Roy)

Analyse van de transcriptionele repressor Kaiso in humane tumoren en
tijdens de celcyclus
- Denayer Tinneke (2-Dec-05; F. Van Roy & K.
Vleminckx)

Functional study of the canonical Wnt pathway using transgenic tools in
Xenopus laevis
- De Craene Bram (19-may-05; F. Van Roy & G.
Berx)

The role of the Snail family of transcription factors in
epithelial-mesenchymal transitions
- Van Belle Tom (25-mar-05; J. Grooten)
IL-15, a cytokine with direct action on CD8+ T cells, exerts an
indirect action on TCR-stimulated CD4+ T cells
- Vanden Berghe Tom (18-feb-05; P. Vandenabeele)

Molecular interplay between apoptotic and necrotic cell death pathways
- Willems An (28-jan-05; N. Mertens & J.
Grooten)

Tumorafhankelijke T cel activering met bispecifieke antilichamen:
optimalisatie door protein-design
- Brouckaert Greet (27-jan-05; P. Vandenabeele)

Analysis of a cellular model for the recognition and phagocytosis of
apoptotic and necrotic cells by macrophages
- Lamkanfi Mohamed (10-nov-04; P. Vandenabeele)

CARD proteins in apoptosis and inflammation
- Reekmans Rieka (23-sep-04; R. Contreras)

Transcriptional profiling of the Bax-responsive genes in S. cerevisiae.
- Vandenbroucke Klaas (10-sep-04; E. Remaut, L.
Steidler & P. Rottiers)

Genetically modified Lactococcus lactis as in vivo delivery system for
trefoil factors at the intestinal mucosa.
- Geysens Steven (28-jun-04; R. Contreras)

Klonering en karakterisering van fungale genen betrokken bij eiwit
N-glycosylatie, kwaliteitscontrole en secretie.
- Vervecken Wouter (28-jun-04; R. Contreras)

Modificatie van de N-glycosylatiesyntheseweg van Aspergillus niger en
Pichia pastoris.
- van Gurp Marjan (25-jun-04; P. Vandenabeele)

Identification of protein-protein interactions in cell death signalling
using the yeast two-hybrid system
- Staelens Jan (31-mrt-04; C Libert)

A molecular genetic analysis of the TNF resistance of the mouse species
Mus spretus
- Bogaerts Sven (13-feb-04; F. Van Roy)

Characterization of a novel zinc finger protein ANC_2H01 (ZASC1)
- Pynaert Gwenda (21-nov-03; J. Grooten)

De regulerende werking van macrofagen op luchtweginflammatie in een
muismodel voor astma
- Vanpoucke Griet (26-sep-03; F. Van Roy & G.
Berx)

The human alpha-catenins : regulation mechanisms controlling their
expression
- Comijn Joke (26-sep-03; F. Van Roy & G. Berx)

SIP1-mediated transcriptional regulation of E-cadherin and
identification of new SIP1 target genes
- Lippens Saskia (12-sep-03; P. Vandenabeele & W.
Declercq)

Expression, regulation and processing of caspase-14 during epidermal
differentiation
- Vanhalst Koen (29-aug-03; F. Van Roy)

Identification and functional analysis of new cadherin genes, possibly
involved in murine brain development
- Buys Emmanuel (23-may-03; P. Brouckaert)

Target validation od soluble guanylate cyclase using conditional
targeted mutagenesis in mice
- Carpentier Isabelle (9-may-03; R. Beyaert)

Molecular and functional characterization of the tumor necrosis factor
receptor associated proteins TRAF1 and TRAF2
- Hostens Jeroen (24-apr-03; P. Brouckaert)

Onderzoek naar het mechanisme van de versterkende werking van IFN-gamma
op het anti-tumoraal effect van TNF
- Janssens Sophie (21-febr-03; R. Beyaert)

Regulation of Interleukin-1 and endotoxin-induced responses by
alternative splicing of MyD88
- Van Oekelen Dirk (28-juni-02; G. Haegeman)
The 5-HT2 receptor family: atypical regulation and functional insight
through altered gene expression using antisense
- van Loo Geert (14-juni-02; P. Vandenabeele)

Apoptotic and necrotic cell death: cell death domain proteins and
release of mitochondrial factors
- Strumane Kristin (14-juni-02; F. Van Roy)

E-cadherin-dependent differential gene expression in cancer cells
reveals the novel E-cadherin-repressed oncogene hECRep1
- Callewaert Nico (31-mei-02; R. Contreras)

Protein N-glycosylation : from yeast to man
- Vermeulen Linda (17-mei-02; G. Haegeman)

Studie van het moleculair mechanisme voor transcriptionele activering
van NF- B p65 na inflammatorische stimulatie
- Bonné Stefan (30-apr-02; F. Van Roy)

Klonering en functionele karakterisering van het desmosomale eiwit
plakophiline-3
- Janssens Barbara (29-mrt-02; F. Van Roy)

Study of two novel members of the human alpha-catenin family
- Wielockx Ben (29-mrt-02; C. Libert & P.
Brouckaert)

De rol van proteasen en de identificatie van genen, coderend voor
beschermende eiwitten, in TNF-geïnduceerde hepatitis en letale shock
- Hochepied Tino (21-sep-01; P.Brouckaert &
C.Libert)

Onderzoek naar de rol van acute-fase proteïnen, in het bijzonder
alfa1-zuur glycoproteïne, in muismodellen voor lokale en systemische
inflammatie
- Van Huffel Sofie (21-sep-01; F. Van Roy &
R.Beyaert)
Identificatie en functionele karakterisering van eiwitten die binden
met het zinkvingereiwit A20
- Vanhauwe Jurgen (15-jun-01; G. Haegeman & J.
Leysen)
Karakterisering van de ligand-bindings- en
signaaltransductie-eigenschappen van humane dopamine D2- en
D3-receptoren
- Francken Bart (17-apr-01; G. Haegeman)
Heterologous expression of G protein-coupled receptors and
reconstituion of G protein coupling : h5-ht5A receptor in mammalian,
insect, and bacterial cells
- De Wilde Gert (10-jan-01; G. Haegeman)
Studie van de ruimtelijke structuur van het TNFR-55 'death domain' en
van de stroomafwaartse signalisatie naar MAP-kinasen
- Schotte Peter (15-dec-00; R. Beyaert &F. Van
Roy)
Studie van caspasen en het activeringsmechanismen
- Van Craenenbroeck Kathleen (21-jun-00; G. Haegeman)

Onderzoek van induceerbare systemen voor heterologene genexpressie in
zoogdiercellen
- Vanlandschoot Ann (10-mei-00; F. Van Roy)
Isolering en karakterisering van catenine- en cadherine-bindende
eiwitten met mogelijke functies in signalisatiewegen en genregulatie
- Laroy Wouter (9-mei-00; R. Contreras)
Structuur-functie analyse van siaalzuur transfererende enzymen
- De Bosscher Karolien (23-mrt-00; G. Haegeman)
Onderzoek naar het mechanisme van Genrepressie door Glucocorticoïden
- Denecker Geertrui (17-mrt-00; W. Fiers & P.
Vandenabeele)
Role of capases and mitochondria in apoptotic and necrontic cell death
- De Backer Marianne (11-feb-00; R. Contreras)
Identification of novel molecular targets for drugs against Candida
albicans
- Dooms Hans (28-jan-00; J. Grooten &F. Van Roy)
Differentiële regulatie van apoptose en celdeling door interleukine-2
en -15 tijdens T-lymfocyt-antwoorden