Research Field: Role of intestinal microbiota in inflammatory pathologies
Team leader: Prof. Dr. Lars Vereecke
Tel: +32 9 33 264 04
The ‘Host-Microbiota Interaction’ lab (HMI) studies host-microbe interactions during the development of various immune disorders and colorectal cancer, using in-house developed transgenic mouse models and germ-free mouse technology. We have a historic interest in inflammatory diseases, and are using TNF overexpressing and A20 conditional knockout mouse lines. In addition, we have great interest in microbiota-driven colorectal cancer (CRC) development, using transgenic microbiota-dependent CRC mouse models. We are investigation both tumor promoting ‘onco-bacteria’ as well as beneficial bacteria during innovative anti-cancer therapies. We also study intestinal goblet-cell biology using unique transgenic approaches. The HMI-lab also established the first Belgian germ-free and gnotobiotic mouse facility a key technology platform for functional microbiota research. Our Facility can rederive transgenic disease models in germ-free conditions, in order to validate microbiota-dependency of various disease mechanisms, and study disease development in reductionistic gnotobiotic settings. Prof. Vereecke also coordinates the ‘Ghent Gut Inflammation Group’, a research consortium around intestinal inflammation at Ghent University.
Areas of expertise
Technology transfer potential
Schematic overview HMI lab. Click to enlarge.
Mucus produced by intestinal goblet cells preventing bacterial adhesion in the colon