Research field: Structural biology
Group leader: Prof. Dr. Savvas SAVVIDES
Our research program in molecular structural biology focuses on the elucidation of structure-function relationships of soluble and membrane-associated proteins and their complexes, with biomedical and biotechnological importance. We employ creative combinations of hybrid approaches involving X-ray crystallography, Small-angle X-ray Scattering (SAXS) and Electron Microscopy (EM), in conjunction with molecular interaction studies and cellular interrogation of the systems under study to elucidate the structural and mechanistic principles underlying the assembly, activation and pathophysiology of protein assemblies pivotal in inflammation, autoimmune diseases and cancer. The cornerstone of our research philosophy lies in a rigorous hypothesis-driven interrogation of the protein complexes under study, and is closely nested in collaborations with leading academic research groups in Belgium and abroad as well as industrial partners.
Area of expertise
Technology transfer potential