Research field: Molecular mechanisms of inflammation and immunityGroup leader: Prof. Dr. Rudi Beyaert Tel:+32 9 33 13 770 - Fax:+32 9 33 13 609 |
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Research topicThe goal of our research is to understand the molecular mechanisms that control inflammation and immunity. We mainly focus on the nuclear factor-kappaB (NF-kB) signaling pathway, which is activated in response to injury, infection, inflammation and other stressful conditions requiring rapid reprogramming of gene expression. Inappropriate NF-kB dependent gene expression is implicated in the pathogenesis of inflammatory diseases and cancer. We are using several molecular and biochemical approaches to generate fundamental knowledge on the biology of a limited subset of molecules that control NF-κB signaling downstream of key cytokine (e.g. TNF, IL-1, IL-33) and immune receptors (e.g. TLR, TCR). The pathophysiological role of our in vitro findings is validated in appropriate disease models (e.g. multiple sclerosis, rheumatoid arthritis, Crohn’s disease, Influenza infection, inflammation associated cancer).
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