Research field: Molecular mechanisms of inflammation and immunityGroup leader: Prof. Dr. Rudi Beyaert Tel:+32 9 33 13 770 - Fax:+32 9 33 13 609 |
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Research topicThe goal of our research is to understand the molecular mechanisms that control inflammation and immunity. We are focusing on specific intracellular signaling cascades, such as the nuclear factor-kappaB (NF-kB) pathway, which is activated in response to injury, infection, inflammation and other stressful conditions requiring rapid reprogramming of gene expression. Inappropriate NF-kB dependent gene expression is implicated in the pathogenesis of inflammatory diseases and cancer. We are using several molecular and biochemical approaches to elucidate the mechanisms that control NF-kB activation downstream of cytokine receptors (TNF, IL-1, IL-33) and immune receptors (TLRs, TCR). Using conditional gene targeting in the mouse we also study the role of key signaling molecules in mouse models of inflammatory diseases (multiple sclerosis, rheumatoid arthritis, asthma, Crohn’s disease), infectious diseases (Pseudomonas or Influenza lung infection), as well as cancer.
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