Research Field: Signal transduction in Inflammation and Cell Death
Team leader: Prof. Dr. Mathieu Bertrand
Tel: +32 9 33 13 720 - Fax: +32 9 221 76 73
Cells are continuously confronted with stress signals that initiate at the cell surface or within the cell. The ability to transduce the signal and to activate a proper cellular response, either through transcription-dependent or –independent mechanisms, relies on the recruitment of adaptor proteins and on the activation of specific signaling pathways. These processes need thigh regulation, as defective control of these pathways can lead to human pathologies.
Our research team focuses on the elucidation of the molecular mechanisms regulating stress-induced cell survival/death, as well as innate immune/inflammatory responses, with a particular interest on the role of ubiquitylation. Cell death and innate immunity are ancient evolutionary conserved, inter-connected, processes that utilize a great number of related molecular effectors and parallel signal transduction mechanisms. Research in the group is mainly conducted at the biochemical and cellular levels, but also involves in vivo studies. Our group is part of the GROUP-ID (Ghent Researchers On Unfolded Proteins in Inflammatory Disease) multidisciplinary research platform (MRP) of Ghent University. GROUP-ID is a consortium that focuses on the role of ER stress in inflammation and immunity.
Areas of expertise
Technology transfer potential
Identification of new therapeutic targets for the treatment of cell death and inflammation related diseases