Research Field: Study of in vivo mechanisms of inflammation-driven autoimmune pathology
Group leader: Prof. Dr. Geert van Loo
Tel: +32 9 33 13 761 - Fax: +32 9 221 76 73
Our research aims to understand the in vivo mechanisms by which inflammation drives (autoimmune) pathology. For these studies we make use of Cre/LoxP-mediated gene targeting technology allowing tissue-specific gene deletion in mice, in combination with mouse models of human inflammatory diseases. Central in our research is the study of the molecular mechanisms involving NF-κB, apoptosis and ER stress in pathologies such as inflammatory bowel disease, rheumatoid arthritis, diabetes and multiple sclerosis.
Areas of expertise
Technology transfer potential
Myelinated axons in brain corpus callosum
Mucus produced by intestinal goblet cells preventing bacterial adhesion in the colon